Pair Name	Toosendanin, Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Endoplasmic reticulum stress
Gene Regulation	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	PARP1	hsa142
	Down-regulation	Expression	ADORA2A	hsa135
	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Expression	TWIST1	hsa7291
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	BT-549	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_1092
	4T1	Malignant neoplasms of the mouse mammary gland	Mus musculus (Mouse)	CVCL_0125
In Vivo Model	2×10⁵ 4T1-fluc-red cells were inoculated in a mammary fat pat of each mouse.
Result	The results suggest that combination of TSN and PTX is superior to PTX alone, suggesting that it may be a promising alternative adjuvant chemotherapy strategy for patients with TNBC, especially those with metastatic TNBC.